Peter Wiedemann Selected Research

Macular Degeneration (Age-Related Maculopathy)

8/2021	PERSEUS 24-month analysis: a prospective non-interventional study to assess the effectiveness of intravitreal aflibercept in routine clinical practice in Germany in patients with neovascular age-related macular degeneration.
3/2021	Importance of continuous treatment with intravitreal aflibercept injections in patients with neovascular age-related macular degeneration-12-month post hoc analysis of the PERSEUS real-world evidence study.
1/2021	Foveal regeneration after resolution of cystoid macular edema without and with internal limiting membrane detachment: presumed role of glial cells for foveal structure stabilization.
1/2020	Osmotic regulation of aquaporin-8 expression in retinal pigment epithelial cells in vitro: Dependence on KATP channel activation.
1/2019	Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation.
12/2018	Hypoxic expression of NLRP3 and VEGF in cultured retinal pigment epithelial cells: contribution of P2Y2 receptor signaling.
1/2018	Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells.
1/2018	Osmotic and hypoxic induction of the complement factor C9 in cultured human retinal pigment epithelial cells: Regulation of VEGF and NLRP3 expression.
1/2018	Aflibercept for Patients with Neovascular Age-Related Macular Degeneration in Routine Clinical Practice in Germany: Twelve-Month Outcomes of PERSEUS.
8/2016	Osmotic induction of placental growth factor in retinal pigment epithelial cells in vitro: contribution of NFAT5 activity.

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Peter Wiedemann Research Topics

Disease

28	Hypoxia (Hypoxemia) 01/2022 - 07/2004
21	Macular Degeneration (Age-Related Maculopathy) 08/2021 - 02/2005
20	Ischemia 01/2021 - 08/2004
17	Diabetic Retinopathy (Retinopathy, Diabetic) 03/2021 - 08/2004
15	Retinal Detachment (Retinal Detachments) 01/2024 - 05/2003
15	Edema (Dropsy) 01/2015 - 09/2004
15	Gliosis 01/2014 - 02/2002
12	Proliferative Vitreoretinopathy 10/2022 - 03/2002
12	Choroidal Neovascularization 07/2021 - 05/2004
11	Inflammation (Inflammations) 01/2019 - 04/2005
10	Retinal Diseases 01/2022 - 08/2004
10	Hypertension (High Blood Pressure) 01/2019 - 01/2015
10	Retinal Vein Occlusion 11/2017 - 05/2008
10	Ganglion Cysts (Ganglion) 01/2015 - 11/2004
9	Macular Edema 04/2020 - 09/2004
8	Epiretinal Membrane (Epiretinal Membranes) 01/2021 - 08/2004
6	Papilledema 10/2016 - 07/2006
5	Necrosis 01/2020 - 03/2005
5	Neoplasms (Cancer) 01/2014 - 03/2005
4	Wounds and Injuries (Trauma) 04/2021 - 07/2009
4	Cataract (Cataracts) 01/2020 - 01/2015
4	Mitochondrial Diseases (Mitochondrial Disease) 07/2016 - 01/2011
4	Type 2 Diabetes Mellitus (MODY) 08/2015 - 11/2010
4	Pathologic Neovascularization 09/2014 - 10/2006
4	Hypertrophy 08/2008 - 08/2005
4	Retinal Neovascularization 04/2007 - 08/2004
3	Retinal Perforations 01/2021 - 01/2019
3	Retinal Degeneration 08/2019 - 08/2005
3	Hyperglycemia 12/2016 - 03/2006
3	Eye Diseases (Eye Disease) 01/2013 - 10/2003
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 01/2017
2	Blindness (Hysterical Blindness) 01/2020 - 06/2005
2	Vision Disorders (Hemeralopia) 01/2020 - 05/2018
2	Retinitis Pigmentosa (Pigmentary Retinopathy) 01/2018 - 01/2011
2	Intraoperative Complications 01/2017 - 01/2016
2	Myopia 01/2013 - 08/2005
2	Melanoma (Melanoma, Malignant) 06/2012 - 12/2003

Drug/Important Bio-Agent (IBA)

81	Retinaldehyde (Retinal)IBA 04/2021 - 05/2003
30	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2021 - 07/2004
12	Proteins (Proteins, Gene)FDA Link 12/2018 - 05/2003
10	SaltsIBA 01/2019 - 01/2015
9	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 08/2016 - 12/2003
7	Retinal Pigments (Pigments, Visual)IBA 01/2022 - 08/2002
7	CytokinesIBA 01/2016 - 07/2004
7	Aquaporins (Water Channels)IBA 01/2015 - 08/2004
7	Glial Fibrillary Acidic ProteinIBA 01/2013 - 08/2004
7	Triamcinolone Acetonide (Azmacort)FDA LinkGeneric 08/2011 - 07/2005
6	Messenger RNA (mRNA)IBA 01/2022 - 03/2006
6	Ranibizumab (Lucentis)FDA Link 07/2021 - 05/2011
5	VimentinIBA 10/2012 - 05/2006
5	pigment epithelium-derived factorIBA 01/2012 - 01/2006
5	Glutamic Acid (Glutamate)FDA Link 01/2008 - 12/2003
4	Adenosine Triphosphate (ATP)IBA 07/2016 - 02/2002
4	SolutionsIBA 03/2016 - 09/2003
4	Heparin-binding EGF-like Growth Factor (HB-EGF)IBA 01/2016 - 06/2005
4	Epidermal Growth Factor (EGF)IBA 01/2016 - 06/2005
4	Triamcinolone (Aristocort)FDA Link 05/2007 - 07/2005
3	Heparin (Liquaemin)FDA LinkGeneric 10/2022 - 06/2005
3	afliberceptIBA 08/2021 - 01/2018
3	Interleukin-6 (Interleukin 6)IBA 01/2021 - 08/2011
3	Angiogenesis Inducing Agents (Angiogenesis Factor)IBA 12/2018 - 07/2004
3	LipidsIBA 07/2016 - 02/2011
3	Transcription Factors (Transcription Factor)IBA 01/2015 - 04/2009
3	1-phenyl-3,3-dimethyltriazene (PDT)IBA 01/2014 - 03/2005
3	AntioxidantsIBA 01/2013 - 07/2006
3	PotassiumIBA 01/2012 - 02/2008
3	Phosphotransferases (Kinase)IBA 09/2011 - 12/2003
3	Streptozocin (Streptozotocin)FDA Link 09/2011 - 10/2008
3	Matrix Metalloproteinases (MMPs)IBA 09/2007 - 01/2006
2	Sucrose (Saccharose)IBA 01/2022 - 12/2016
2	Dexamethasone (Maxidex)FDA LinkGeneric 04/2020 - 09/2016
2	Purinergic Receptors (Receptors, Purine)IBA 12/2018 - 09/2011
2	InflammasomesIBA 12/2018 - 01/2016
2	Capsules (Microcapsules)IBA 01/2017 - 01/2016
2	Glucose (Dextrose)FDA LinkGeneric 12/2016 - 06/2012
2	EnzymesIBA 12/2016 - 01/2014
2	Vascular Endothelial Growth Factor BIBA 08/2016 - 08/2011
2	Caspase 3 (Caspase-3)IBA 01/2014 - 12/2011
2	A-Form DNA (A-DNA)IBA 01/2014 - 01/2013
2	Thrombospondin 1IBA 01/2014 - 07/2004
2	Photosensitizing Agents (Photosensitizers)IBA 01/2014 - 03/2005
2	ProstaglandinsIBA 08/2012 - 08/2012
2	Transforming Growth Factor beta (TGF-beta)IBA 08/2012 - 06/2006
2	cobaltous chloride (cobalt(II)chloride)IBA 08/2012 - 01/2012
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 08/2012 - 04/2009
2	Arachidonic Acid (Vitamin F)IBA 08/2012 - 12/2005
2	Carisoprodol (Soma)FDA LinkGeneric 06/2012 - 12/2005
2	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 01/2012 - 09/2011
2	Bevacizumab (Avastin)FDA Link 01/2012 - 12/2011
2	AntibodiesIBA 01/2012 - 10/2010
2	Ion Channels (Ion Channel)IBA 12/2011 - 05/2007

Therapy/Procedure

7	Lasers (Laser) 01/2024 - 04/2009
5	Traction 01/2021 - 02/2013
5	Vitrectomy 01/2020 - 06/2003
4	Therapeutics 01/2014 - 11/2010
4	Photochemotherapy (Photodynamic Therapy) 01/2014 - 03/2005
3	Intraocular Lens Implantation 01/2017 - 01/2015
2	Injections 08/2021 - 03/2021
2	Light Coagulation 10/2014 - 05/2014
2	Intravitreal Injections 09/2013 - 12/2011